Week 2 of the NFL schedule kicks off Thursday with an AFC East matchup between the Buffalo Bills and slight favorites Miami Dolphins and will conclude on Monday Night Football when Jalen Hurts and the Philadelphia Eagles play their home -- and North American -- opener against the Atlanta Falcons.
The Las Vegas Raiders opened as the biggest underdogs of the week as they're getting more than a touchdown in their road date with the Baltimore Ravens, while the biggest total on the slate belongs to the Tampa Bay Buccaneers and Detroit Lions for their Sunday afternoon game in Detroit. C.J. Stroud and theHouston Texansare giving up 6.5 points to Caleb Williams and the Chicago Bears for Sunday's night game.
Here's a look at all the Week 2 games. Football Power Index (FPI) by ESPN Sports Analytics. Odds current as of publication time. For most current odds go to ESPN BET
Thursday 8:15 PM ET, Prime Video
Money Line: Bills (+105) ; Dolphins (-125)
Total: 48.5; Opened: 50.5
FPI favorite: Bills by 0.3
Sunday 1:00 PM ET, CBS
Money Line: 49ers (-270) ; Vikings (+220)
Total: 45.5; Opened: 46.5
FPI favorite: 49ers by 5.1
Sunday 1:00 PM ET, CBS
Line movement: opened Chargers -3
Money Line: Chargers (-290) ; Panthers (+240)
Total: 39.5; Opened: 42
FPI favorite: Chargers by 7
Sunday 1:00 PM ET, FOX
Money Line: Colts (-170) ; Packers (+145)
Total: 40.5; Opened: 47.5
FPI favorite: Colts by 1.7
Sunday 1:00 PM ET, FOX
Money Line: Giants (+105) ; Commanders (-125)
Total: 43.5; Opened: 42.5
FPI favorite: Commanders by 4.3
Sunday 1:00 PM ET, FOX
Money Line: Saints (+230) ; Cowboys (-280)
Total: 45.5; Opened: 44.5
FPI favorite: Cowboys by 4.1
Sunday 1:00 PM ET, CBS
Money Line: Browns (+145) ; Jaguars (-170)
Total: 41.5; Opened: 44.5
FPI favorite: Jaguars by 2.9
Sunday 1:00 PM ET, CBS
Money Line: Jets (-195) ; Titans (+165)
Total: 41.5; Opened: 44
FPI favorite: Jets by 2.9
Sunday 1:00 PM ET, FOX
Money Line: Buccaneers (+270) ; Lions (-340)
Total: 51.5; Opened: 48.5
FPI favorite: Lions by 6
Sunday 1:00 PM ET, CBS
Line movement: opened Ravens -7.5
Money Line: Raiders (+360) ; Ravens (-450)
Total: 41.5; Opened: 44
FPI favorite: Ravens by 9
Sunday 1:00 PM ET, FOX
Money Line: Seahawks (-175) ; Patriots (+150)
Total: 38.5; Opened: 42.5
FPI favorite: Seahawks by 2.4
Sunday 4:05 PM ET, FOX
Money Line: Rams (+105) ; Cardinals (-125)
Total: 49.5; Opened: 47.5
FPI favorite: Rams by 1.2
Sunday 4:25 PM ET, CBS
Line movement: opened Chiefs -3.5
Money Line: Bengals (+210) ; Chiefs (-250)
Total: 48.5; Opened: 48.5
FPI favorite: Chiefs by 6.2
Sunday 4:25 PM ET, CBS
Money Line: Steelers (-155) ; Broncos (+135)
Total: 36.5; Opened: 40.5
FPI favorite: Steelers by 3.9
Sunday 8:20 PM ET, NBC, Peacock
Money Line: Bears (+250) ; Texans (-300)
Total: 45.5; Opened: 46.5
FPI favorite: Texans by 5.9
Monday 8:15 PM ET, ESPN
Line movement: opened Eagles -4
Money Line: Falcons (+230) ; Eagles (-280)
Total: 47.5; Opened: 48.5
FPI favorite: Eagles by 5.7